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BACKGROUND:  Depression occurs in approximately 5% of the US population affecting 19 million people. Depression is the leading cause of disability of people ages 18-45 with an annual economic burden exceeding 50 billion dollars. Despite recent advancements in the medication for depression, nearly 2/3 of patients who receive treatment with antidepressant medication do not get even a 50% improvement in symptoms.  Lingering symptoms impact social and occupational functioning, overall quality of life and may result in relapse back to full-blown symptoms. Researchers want to study a new class of medications for treating depression.

STUDY:  Researchers are conducting a 16-week study of antidepressants and corticotropin releasing factor (CRF), a chemical which occurs naturally in the body. Researchers will study what role CRF plays in treating symptoms of depression.

ELIGIBILITY:  If you are between the ages of 18 and 65, have been diagnosed with Major Depressive Disorder and have had limited improvement with your current medication you may be eligible.

INFORMATION:  Enrollment for this study is closed. Please check back for new studies on Major Depression.

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